Plant Transcription Factor Database
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G52880.1
Common NameANAC018, ATNAM, F14G24.15, NAC018, NAM, NARS2
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family NAC
Protein Properties Length: 320aa    MW: 35442.7 Da    PI: 8.5708
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G52880.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          NAM   1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlsk... 95 
                  lppGfrFhPtdeelv +yLk+k+++ +l++  +i++vd+yk++Pw+Lp+k++ +e+ewyfFs+rd+ky++g r+nra++sgyWkatg+dk+v+s+   
                  79****************************.88***************999999****************************************9998 PP

          NAM  96 kgelvglkktLvfykgrapkgektdWvmheyrl 128
                  ++++vg+kk Lvfy+g+ pkg+k+dW+mheyrl
                  8899***************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019414.97E-6512178IPR003441NAC domain
PROSITE profilePS5100561.90717177IPR003441NAC domain
PfamPF023651.2E-2718146IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0045995Biological Processregulation of embryonic development
GO:0048317Biological Processseed morphogenesis
GO:0080060Biological Processintegument development
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009025anatomyvascular leaf
PO:0009052anatomyflower pedicel
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 320 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3ulx_A4e-731618014171Stress-induced transcription factor NAC1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.110240.0flower| leaf| seed| silique
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT1G52880-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Restricted primarily to the region of the embryo including the SAM (PubMed:12175016). Expressed in the outer integument, but seems not expressed in the embryo at the torpedo stage (PubMed:18849494). {ECO:0000269|PubMed:12175016, ECO:0000269|PubMed:18849494}.
Functional Description ? help Back to Top
Source Description
TAIRTranscription factor with a NAC domain. Homologous to the petunia gene NAM which is required for the development of the shoot. Expressed in the embryo.
UniProtMay encode a transcription factor involved in the elaboration of shoot apical meristems (SAM) (Probable). Together with NAC056/NARS1, regulates embryogenesis by regulating the development and degeneration of ovule integuments, a process required for intertissue communication between the embryo and the maternal integument (PubMed:18849494). {ECO:0000269|PubMed:18849494, ECO:0000305}.
Function -- GeneRIF ? help Back to Top
  1. NARS1/NAC2 and NARS2/NAM regulate embryogenesis by regulating the development and degeneration of ovule integuments.
    [PMID: 18849494]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT5G61850 (A)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT5G61850(A)
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G53170, AT1G77450
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: When associated with disruption in NAC056/NARS1, abnormally shaped seeds, defect in embryogenesis arrested at the torpedo-shaped embryo stage, markedly delayed integuments degeneration, and delay of silique senescence. {ECO:0000269|PubMed:18849494}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G52880
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF1233110.0AF123311.1 Arabidopsis thaliana NAC domain protein NAM mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_175696.10.0NAC domain-containing protein 18
SwissprotQ9ZNU20.0NAC18_ARATH; NAC domain-containing protein 18
TrEMBLR0I6X80.0R0I6X8_9BRAS; Uncharacterized protein (Fragment)
STRINGAT1G52880.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP1715800
Publications ? help Back to Top
  1. Kikuchi K, et al.
    Molecular analysis of the NAC gene family in rice.
    Mol. Gen. Genet., 2000. 262(6): p. 1047-51
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  3. Duval M,Hsieh TF,Kim SY,Thomas TL
    Molecular characterization of AtNAM: a member of the Arabidopsis NAC domain superfamily.
    Plant Mol. Biol., 2002. 50(2): p. 237-48
  4. Xie Q, et al.
    SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals.
    Nature, 2002. 419(6903): p. 167-70
  5. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  6. Ooka H, et al.
    Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana.
    DNA Res., 2003. 10(6): p. 239-47
  7. Zimmermann R,Werr W
    Pattern formation in the monocot embryo as revealed by NAM and CUC3 orthologues from Zea mays L.
    Plant Mol. Biol., 2005. 58(5): p. 669-85
  8. Kim YS, et al.
    A membrane-bound NAC transcription factor regulates cell division in Arabidopsis.
    Plant Cell, 2006. 18(11): p. 3132-44
  9. Zhong R,Demura T,Ye ZH
    SND1, a NAC domain transcription factor, is a key regulator of secondary wall synthesis in fibers of Arabidopsis.
    Plant Cell, 2006. 18(11): p. 3158-70
  10. Demura T,Fukuda H
    Transcriptional regulation in wood formation.
    Trends Plant Sci., 2007. 12(2): p. 64-70
  11. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
  12. Kunieda T, et al.
    NAC family proteins NARS1/NAC2 and NARS2/NAM in the outer integument regulate embryogenesis in Arabidopsis.
    Plant Cell, 2008. 20(10): p. 2631-42
  13. Blein T, et al.
    A conserved molecular framework for compound leaf development.
    Science, 2008. 322(5909): p. 1835-9
  14. Yoshiyama K,Conklin PA,Huefner ND,Britt AB
    Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damage.
    Proc. Natl. Acad. Sci. U.S.A., 2009. 106(31): p. 12843-8
  15. Kim SG,Park CM
    Membrane-mediated salt stress signaling in flowering time control.
    Plant Signal Behav, 2007. 2(6): p. 517-8
  16. Yabuta Y, et al.
    Identification of recognition sequence of ANAC078 protein by the cyclic amplification and selection of targets technique.
    Plant Signal Behav, 2010. 5(6): p. 695-7
  17. Wang H, et al.
    Mutation of WRKY transcription factors initiates pith secondary wall formation and increases stem biomass in dicotyledonous plants.
    Proc. Natl. Acad. Sci. U.S.A., 2010. 107(51): p. 22338-43
  18. Gaudinier A, et al.
    Enhanced Y1H assays for Arabidopsis.
    Nat. Methods, 2011. 8(12): p. 1053-5
  19. Lee S,Park CM
    Regulation of reactive oxygen species generation under drought conditions in Arabidopsis.
    Plant Signal Behav, 2012. 7(6): p. 599-601
  20. Li J, et al.
    miRNA164-directed cleavage of ZmNAC1 confers lateral root development in maize (Zea mays L.).
    BMC Plant Biol., 2012. 12: p. 220
  21. Singh AK,Sharma V,Pal AK,Acharya V,Ahuja PS
    Genome-wide organization and expression profiling of the NAC transcription factor family in potato (Solanum tuberosum L.).
    DNA Res., 2013. 20(4): p. 403-23
  22. Wei H,Yordanov YS,Georgieva T,Li X,Busov V
    Nitrogen deprivation promotes Populus root growth through global transcriptome reprogramming and activation of hierarchical genetic networks.
    New Phytol., 2013. 200(2): p. 483-97
  23. Lumba S, et al.
    A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis.
    Dev. Cell, 2014. 29(3): p. 360-72
  24. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
  25. Aida M,Ishida T,Fukaki H,Fujisawa H,Tasaka M
    Genes involved in organ separation in Arabidopsis: an analysis of the cup-shaped cotyledon mutant.
    Plant Cell, 1997. 9(6): p. 841-57